General Information

  • ID:  hor005196
  • Uniprot ID:  P68274
  • Protein name:  Glucagon
  • Gene name:  GCG
  • Organism:  Oryctolagus cuniculus (Rabbit)
  • Family:  Glucagon family
  • Source:  animal
  • Expression:  Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Oryctolagus (genus), Leporidae (family), Lagomorpha (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction; GO:0050896 response to stimulus
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
  • Length:  29
  • Propeptide:  HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
  • Signal peptide:  NA
  • Modification:  T2 Phosphoserine
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: <10 minutes; /600 seconds ( PubMed ID: 20418955 )

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P68274-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P68274-F1.pdbhor005196_AF2.pdbhor005196_ESM.pdb

Physical Information

Mass: 398239 Formula: C153H225N43O49S
Absent amino acids: CEIP Common amino acids: S
pI: 7.54 Basic residues: 4
Polar residues: 11 Hydrophobic residues: 7
Hydrophobicity: -98.97 Boman Index: -8379
Half-Life: 3.5 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 40.34
Instability Index: 5602.76 Extinction Coefficient cystines: 8480
Absorbance 280nm: 302.86

Literature

  • PubMed ID:  5011077##20418955
  • Title:  Rabbit glucagon: isolation, crystallization and amino acid composition.